The higher Sbalanced scores for both CORAL methods over the other methods suggest that the core constraint played a significant role in improving performance for several families.
Constructing high-quality alignments between well-defined core regions, in contrast, benefits tremendously from the core constraint.
For some families, including Macro and PDZ, all members benefited from the core constraint.
The core constraint may be incorporated into other alignment algorithms as well.
Masson-Delmotte, V. et al. Past and future polar amplification of climate change: climate model intercomparisons and ice-core constraints.
However, given the shared nature of the human resource crisis across contexts and a degree of nationally determined standardisation of the ART programme, it is safe to claim that the study indeed highlights core problems and constraints in the rollout of the public ART programme in South Africa and, therefore, also furnishes important lessons for other provinces and countries.
However, interestingly, six residues with elevated ω were identified in the core interface of Mecopterida ECR, suggesting that the dimerisation core of ECR, like that of USP/RXR, may also be under relaxed constraint in the Mecopterida clade [ 50].
It drives continuous improvement as teams attack constraint after constraint in pursuit of perfection.
Consistent with the assumption that selection pressure is higher in tRNAs belonging to the core set, we are able to observe higher constraints in tRNAs from the core set compared with the peripheral set for all species pairs.
However, the exact opposite is observed, which justifies our separation of the data in two sets and confirms higher constraints in the core set.
