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Notably, the hydrophobic sliding mechanism is supported experimentally by Mittal et al. by showing that disulfide cross-links (Gly16Cys/Leu38Cys) that exert a conformational restraint on the hydrophobic core compromise protease activity, and that activity can be largely restored through reduction of the cross-links.
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1 Any activity that alters CBF during the acute phase of ischaemic stroke may, at least theoretically, directly contribute to extension of the penumbra to the ischaemic core and compromise clinical outcome.
I think what people do not like is when our leaders compromise core principles without a fight.
His proposal that homosexuals compromise core values for civil rights is ludicrous, offensive and scary coming from a man of the cloth.
The core of the compromise is that SoundExchange has granted a 40-50% reduction in the per-song-per-listener minimum rates in exchange for us giving them a 25% share of our US revenue.
It is remarkable that changes including mutational changes, leading to a complete redesign of its hydrophobic core do not compromise the structural integrity of this protein.
Inadequate data quality may impair our understanding of the true epidemiology of TB, compromise core program functions, and undermine our ability to meet program objectives and goals.
You shouldn't compromise your core interests, your core needs, your core values.
But the passage of time also offers an opportunity for deeper reflection on how the core promises and compromises of BHR have played out on the ground.
Compromise is the soul of politics, but compromising core American values is unacceptable.
"I don't compromise my core sense of principles.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com