It is intended to avoid duplication of recording of information for clinical and research purposes, and hence allows collection of a routine core clinical data set, including injury severity, pain intensity and WAD grade diagnosis.
Potential unmeasured confounding due to lack of core clinical data.
The validity of these animal preparations as animal models for schizophrenia is generally based upon the extent to which they induce measurable behavioral changes that are homologous or analogous to the core clinical features or the information processing endophenotypes (presymptom phenotypes) that are seen in schizophrenia.
A further 119 (49%) could be measured using a core clinical registry, which contains information on important prognostic factors (e.g., clinical stage, physiological reserve, hormone-receptor status).
In HES, individual patients are allocated the same identifier for each episode of care[ 9] and core fields contain patient demographics, clinical information, and hospital administrative data.
For the purposes of this study we assumed that a core clinical registry could collect complete information on all initial treatments, even those done in ambulatory care settings.
28 Information on core clinical variables, such as time of onset of symptoms, cardiac biomarkers, ECG findings or left ventricular ejection fraction, was not available to us; neither was information on prehospital data or out-hospital deaths.
Demner-Fushman et al. [ 35] have used the PICO (Population/Problem, Intervention, Comparison, Outcome) Framework as a basis for extracting clinically relevant information from Medline abstracts from core clinical journals.
The analyses were performed independently by two experienced independent observers in an independent core laboratory (Kokura Memorial Hospital, Kitakyushu, Japan) blinded to the clinical information.
