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The core clinical features of DLB include fluctuating cognition, visual hallucinations, and movement symptoms.
The validity of these animal preparations as animal models for schizophrenia is generally based upon the extent to which they induce measurable behavioral changes that are homologous or analogous to the core clinical features or the information processing endophenotypes (presymptom phenotypes) that are seen in schizophrenia.
The core clinical features of UCB encephalopathy may range from mild mental retardation and subtle cognitive disturbances to deafness and severe cerebral palsy, seizure or death from kernicterus [2], [5].
At least one of the core clinical features must be present: 1) Cognitive.
The core clinical features of DLB are fluctuating cognition, recurrent visual hallucinations, and motor features of Parkinson's disease.
That is, the population prevalence of most of the core clinical features and many of the supplemental features of TES presented below is relatively high.
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It represents a core clinical feature of the vmPFC lesion syndrome, which is also present in mania, substance abuse and problem gambling.
Although dementia is a core clinical feature, most studies have focused on the neurological and psychiatric, rather than the specifically cognitive, signs and symptoms.
The progressive dying-back axonopathy represents the core clinical feature of adrenomyeloneuropathy (AMN) in male patients, with onset usually between 20 and 30 years and in heterozygous females with onset between 40 and 50 years.
To be included as a core clinical feature, the sign or symptom must have been reported in a minimum of 70% of the cases in the study by Stern and colleagues [ 14] of neuropathologically confirmed cases of pure CTE.
It is often under-recognized in the clinic, in part because the core clinical diagnostic features – fluctuations in cognition, visual hallucinations, and parkinsonism – are nonspecific and subject to varied interpretation.
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