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This idea may explain why CHR2 carries features typical for plasmid-type partitioning, as well as its unique core cellular functions.
The nucleolus is traditionally associated with highly conserved protein families and core cellular functions.
These results support the hypothesis of a minimal set of core cellular functions activated by the envirome.
HSF1 also orchestrates a broad network of core cellular functions associated with proliferation, survival, protein synthesis and glucose metabolism, thus enhancing oncogenic transformation [ 8, 9].
Nonetheless, it is interesting to note that this group was also significantly depleted in transcripts encoding proteins involved in core cellular functions such as translation functions.
However, there is an opportunity to exploit synthetic lethalities specific to particular populations of cancer cells created by the homozygous loss of genes responsible for core cellular functions.
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The regulation of 11 sulfatases during stressful conditions suggests that these genes are heavily involved in the core cellular function of R. baltica.
It is conceivable, then, that SET2 subtype genes have been conserved for RNase polymerase II-interaction as a core cellular function and, thus, unlinked with multicellularity.
All cancers result from the cumulative acquisition of molecular defects within a basic core of cellular functions that control proliferation, apoptosis, and invasiveness (Hanahan and Weinberg, 2000).
Metabolism is the core of cellular functions, and comprises numerous reactions that function in the degradation of nutrients and biosynthesis of cellular components including proteins, lipids, carbohydrates, DNA, and RNA.
These protein families might be responsible for core cellular and physiological functions of the B. tabaci complex.
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