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How do the core cell death proteins in sympathetic neurons function in axon degeneration induced by local NGF deprivation?
Several fungi-specific families as well as components of the core cell death machinery shared by filamentous fungi and metazoan were identified.
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PCD is mediated by the core cell-death machinery consisting of proteins that mediate and control the activation of caspases – enzymes that dismantle cellular architecture during apoptosis.
In C. elegans, programmed cell death is believed to be molecularly initiated by the activation of a core cell-death pathway, consisting of egl-1, ced-9, ced-4, and ced-3 (Metzstein et al. 1998).
In other cases, as stroke or tissue infarction, a hypoperfused, hypoxic, meta-stable region, named the penumbra, is formed around the core of necrotic cell death.
The core machinery of cell death, however, seems to be formed by a discreet number of protein families (Fig. 2).
These data show that thaspine treatment was able to kill the cells in the spheroid cores, but that cell death was not by apoptosis.
Caspases form the core activation of apoptotic cell death.
Pathophysiological analysis after focal brain ischemia reveals a necrotic core area of irreversible cell death resulting from total bioenergetic failure due to dramatically reduced metabolic rates of oxygen and glucose.
As a core executor in caspase-independent cell death, AIF is intensively studied [ 11].
Curcio et al. reported that the spheroid radii greater than 200 μm rendered cells in their core vulnerable to hypoxia and cell death [ 31].
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