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C-MYC and CDK1 are two key regulators of the cell cycle and, accordingly, the top 5 enriched process networks found in AR-V high bone metastases were; Cell cycle Core, Cell cycle S phase, Cell cycle Mitosis, Cytoskeleton spindle microtubules and Cell cycle G2-M.
Previously unknown features of the core cell cycle circuit were identified, including 107 antisense TSSs which exhibit cell cycle-control, and 241 genes with multiple TSSs whose transcription levels often exhibited different cell cycle timing.
Within the core cell cycle network, the genes mostly showed conserved co-expression, belonging to either O1 or O2 clusters (Figure 1-E).
In contrast, outside of the core cell cycle network, many cell cycle related genes showed a divergent co-expression (Table S1).
We conclude that Sei1 plays an important role in pancreatic β-cells, which supports a functional link between Sei1 and the core cell cycle regulators specifically in the context of the pancreas.
We have taken a dual approach to examine cell division control in ept mutant eye-antennal tumors: we have sought to identify genetic manipulations that suppress ept tumor growth, and in parallel we have characterized the effect of ept loss on cell cycle phasing and expression of core cell cycle regulatory factors.
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Similarly, we investigated the expression of Arabidopsis core cell-cycle gene homologs in Japanese cedar.
This establishes a direct link between core cell-cycle components and transcription factors in organizing the root stem cell niche.
Druart et al [ 36] reported the expression of 68 homologs of aspen trees based on 80 core cell-cycle genes that were investigated in Arabidopsis[ 37].
In addition, we highlighted the molecular dynamics of core cell-cycle regulators in the male gametophyte and postulated the first genetic model to account for the differential timing of spermatogenesis among angiosperms and its coordination with female gametogenesis.
Pollen tubes grown for 4 to 48 h in vitro were used to verify the microarray expression by real-time quantitative RT-PCR (qRT-PCR) and to establish expression patterns of core cell-cycle regulators.
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