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These nanostructures provide three regions for modification with bioactive agents, namely, the core, branching zone, and branch surface [13].
PAMAM Dendrimers are synthetic spherical macromolecules with a well-defined surface, comprising a core, branching sites and a large number of terminal groups [12].
Altogether our data demonstrate that not LAM capping, but mannan core branching of LM/LAM plays an important role in mycobacterial pathogenesis in the context of innate immunity.
Strikingly, restoration of mannan core branching in the mptC mutant was sufficient to fully complement the in vivo phenotype in embryos.
The level of mannan core branching is one of the structural features that determines TLR-2 activity (Nigou et al., 2008).
It is intriguing though that in the M. marinum zebrafish infection model an effect of LM and/or LAM mannan core branching on virulence can be shown.
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The council has said it wants to have a "core branch network" of libraries.
We've seen in our lifetimes a rapid evolution in the wearables family — it has brought together four core branches of technology into a new class of device.
The incorporation of photoresponsive moieties at various components of dendrimer such as core, branches or at the peripheral end exaggerates its significance in various allied fields of nanotechnology which includes sensors, photoswitch, electronic widgets and in drug delivery systems.
The dendrimer structure, consisting of a core, branched interiors, and numerous surface functional groups, serves as a platform to which additional substrates can be added to this spherical molecule in a highly controlled manner.
These α-glucans are composed of a 4-α-DGlc-1 core branched at position 6 every five or six residues by 4-α-D-Glc-1 oligoglucosides [ 7, 8, 10].
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