The basic principles of these core analyses are fairly simple, but the strength of these analyses is their ability to be seamlessly run across multiple genomes to prioritize all variants and genes at once.
To determine which pathways are significantly regulated by alteration of CXCR7 expression, lists of proteins detected by antibody array (Supplementary Tables S2 and S3) were imported into the ingenuity pathway analysis (http://www.ingenuity.com; Ingenuity Systems) and core analyses were performed.
If the exposure data at index date 3 are insufficient, then SAC endorsed the use of index date 2. The analgesic groups analyzed in the "core analyses" are not mutually exclusive.
The significant networks revealed from the IPA core analyses are shown in Figs. 1, 2 and 3 for the focus genes reported to be associated with platinum-, taxane- and platinum/taxane- induced neuropathy, respectively.
The core sample for these analyses was limited to singletons who survived to 1 year (n = 13,617).
Hence, the core model for all analyses was: (1) Y ijk = α i + α ij + β 1ij N L k + β 2ij D P F k + β 3ij D P F k N L k + ε ijk where Yij is the trait value for individual k in deme j (j∈{1,2,3,4}) and group i (i∈{warm, cold}).
The number of cancer tissue cores suitable for immunohistochemical analyses was 72, which comprised PAC (n=34) and AAC (n=20), and cholangiocarcinoma (n=18) (Table 2).
All core analyses will be conducted with and without imputation for individual variables, including variables that will be imputed at the level measurement, that is, before aggregation to form hospital-level measures.
Special core analyses (SCAL) were carried out on Well-9 from Area B. The measurements included porous plate capillary pressure and centrifugal water oil capillary pressure.
There were performed several analyses: the first analysis assumed that operators take no action or their actions are not successful to provide the coolant injection to the reactor core; the other analyses were performed to investigate the accident management measures to restore the core cooling at different temperatures of the reactor core.
