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The effect of un-engineered (naïve) human umbilical cord matrix stem cells (hUCMSC) on the metastatic growth of MDA 231 xenografts in SCID mouse lung was examined.
Un-engineered human and rat umbilical cord matrix stem cells (UCMSCs) attenuate growth of several types of tumors in mice and rats.
The microfibrous mat housed mesenchymal stem cells (MSCs) from human umbilical cord matrix (Wharton's Jelly) aligned in parallel to each other in a similar way to cell organization in native myocardium.
Previous work indicated that pig umbilical cord matrix (pUCM) cells are a type of primitive stem cell and that these cells could be recovered after central or peripheral injection into rats that did not receive immune suppression therapy.
The aim of our experiment was to investigate the role of small molecules in survival of Islet like cell aggregates (ICAs) engineered from umbilical cord matrix under oxygen deprived condition (<5% O2).
This work shows that the active interaction between human umbilical cord matrix stem cells and Poly (l-lactide)acid (PLLA) and PLLA/Multi Walled Carbon Nanotubes (MWCNTs) nanocomposite films results in the stem cell assembly as a spheroid conformation and affects the stem cell fate transition.
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In this study, we fused immortalized GES-1 cells with cord matrix-derived mesenchymal stem cells (CM-MSCs).
(AT-MSC: adipose tissue-derived MSC; di-MSC: MSC isolated by digestion method; ex-MSC: MSC isolated by explant technique; IQR: interquartile range; MSC: multipotent mesenchymal stromal cell; SDFT-MSC: tendon-derived MSC; UCM-MSC: umbilical cord matrix-derived MSC).
(AT-MSC: adipose tissue-derived MSC; di-MSC: MSC isolated by digestion method; ex-MSC: MSC isolated by explant technique; IOD: index of osteogenic differentiation; IQR: interquartile range; MSC: multipotent mesenchymal stromal cell; SDFT-MSC: tendon-derived MSC; UCM-MSC: umbilical cord matrix-derived MSC).
Cartilage tissue resulted in more resistance to cell removal compared to Wharton's jelly; already one cycle induced an appreciable disappearance of cellular elements in the umbilical cord derived matrix.
Several reports indicate that cells from Wharton's Jelly (WJ), the main component of the umbilical cord extracellular matrix, are multipotent stem cells, expressing markers of bone marrow mesenchymal stem cells (BM-MSCs).
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