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Description: Copy of segment is also in Paiute LA 236.
Description: Copy of segment is also in Shoshoni LA 235.
Some molecules with segment 9 translocations contain another copy of segment 10 at its original micronuclear position (Mn101005-20 and Mn101005-14 in Figure S5), suggesting the possibility of either intermolecular recombination or additional error; however we cannot exclude intra-molecular replication or PCR error to explain the segment 10 duplications.
Note that for a given ape and a segment ϕ i = (ϕ i ℓ, ϕ i r ), the breakpoint interval Br i ape can easily be computed using the set of conditions given in Section 2. Now we present an efficient algorithm to find the maximal valid clusters supporting copy of segment ϕ i =(ϕ i ℓ, ϕ i r ) to any location in genome (the algorithm can trivially be extended for other segments in Φ).
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It is trivial to see that finding maximal valid clusters for all copies of segment ϕ i =(ϕ i ℓ, ϕ i r ) into any position in the genome is equivalent to finding all maximal intersecting breakpoint intervals for all paired-end read mappings ape i.
Typically, loss-of-function mutations in the BX-C result in the transformation of a given segment into a copy of the segment directly anterior to it.
The hidden state at segment t is denoted as xg(t), which is the true copy number of segment t and is unknown.
For example, if the absolute copy number of segment j is 2, then the compatible allelic configurations are PP, MM and PM, where P and M denotes the paternal and maternal allele of the tumor genome, respectively.
For cases involving the copying of segments from a copyrighted catalog by photographic reproduction, see Hedeman Products Corp. v. Tap-Rite Prods. Tap-Rite Prods
Central to this region and other regions of 22q11.2 is the presence of multiple copies of segments of the Translocation Breakpoint Type A sequence (GenBank, AB261997) [ 12].
Our first formulation is a nucleotide-level alignment model that assumes the transcript sequence is a chain of unidirectional copies of segments taken from the genome as investigated in Ergün et al. (2003).
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