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It is possible that more than one family of MITEs evolved from a unique master copy, generating diverse families that keep on transposing and evolving depending on the presence of an active element in the genome, as has been demonstrated for P elements in the An.
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They began discussing the coverage that Madeleine K. Albright, the new Secretary of State, was getting that week: the Newsweek cover that gushed "Mad About Madeleine," the stories about her children and her divorce, the huge amount of copy generated by the discovery that her grandparents were Jewish and had died in the Holocaust.
These self-replicating sequences are suppressed by hypermethylation because the vegetative copy generates integrative copies resulting in the harmful influence of insertion mutagenesis.
They achieve hypermutation through replacement of the variable region with a strongly mutated cDNA copy generated by the element-encoded reverse transcriptase.
In Aedes, the early duplication from the ancestral copy generated the VgA/ B lineage, which underwent an additional duplication to generate 3 Vtg copies - these duplication events occurred prior to the divergence of the Aedes and Ochlerotatus genera.
His children's books have sold 60 million copies, generating a merchandise industry and Hollywood adaptations.
When the book won a Caldecott Medal, the publisher ordered a new printing of 80,000 copies, generating a fat check that bought the once-unaffordable additions.
Wreden's game has sold six hundred thousand copies, generating an estimated 6.3 million dollars for him and the game's artist, a British teen-ager named William Pugh.
Every printing of an early modern book was slightly different; hence the oddity of the Norton Facsimile edition of the First Folio, which reproduced the cleanest version of each page from different copies, generating the facsimile of a volume that never existed.
His games have sold millions of copies, generating hundreds of millions of dollars in revenues.
She basis her estimate on the fact that the book has sold 9 million copies generating $135 million in sales not including sales of a movie tie-in version of the book which is currently a best seller.
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