Sentence examples for copy changes in from inspiring English sources

To identify regions of copy number gain/loss, we developed a new segmenting method called "SWITCHdna" (Sup Wald Identification of copy CHanges in dna ).

In the late-breaking abstract section, John Bartlett (University of Glasgow, Glasgow, UK) described the use of genomic microarrays to detect copy changes in microdissected breast tumours.

BAC-based CGH arrays were amongst the first genomic arrays to be introduced [ 9] and are routinely used to detect single copy changes in the genome, owing to their high sensitivity.

Bacterial Artificial Chromosomes (BAC) based CGH arrays were amongst the first genomic arrays to be introduced [ 1] and are routinely used to detect single copy changes in the genome, owing to their high resolution in the order of 1 Mb [ 1, 2].

One-copy changes in the DNA-diploid stage may give large shifts of the G/R ratio, even after tetraploidization, whereas those after tetraploidization undergo small shift.

The present study was designed to assess the effects of DOP-PCR and labeling method on the sensitivity of metaphase- and array-based CGHs in the detection of one-copy changes in near-tetraploid Kato-III cells.

The sensitivity and specificity in CGH analyses largely depend on the unbiased amplification and labeling of probe DNA, and the sensitivity and specificity should be high enough to detect one-copy changes in aneuploid cancer cells when accurate assessment of chromosomal instability is needed.

In today's issue of Nature, the team reports that the flight patterns showed a definite hierarchy, with most or all of the birds consistently copying changes in direction by the flock's leaders, which almost always flew in front.

Three molecular signatures can reveal early stages of functional divergence between gene copies: change in the level of purifying selection between paralogous genes, occurrence of positive selection, and transient relaxed purifying selection following gene duplication.

We also clarify that we are interested in somatic copy number changes in tumors, rather than heritable copy number variants (CNVs).

All gene copy number changes in individual samples are shown in the Additional file 2: Copy number changes detected by aCGH analysis.