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In a total of 92 cases of primary tumors, 8 (8.7%) had more than 4 copies, with the highest number being 7.8 copies (Fig. 3b).
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Then during iterations of the EM algorithm, the copy with the highest score according to the current estimate of the target PSWM is chosen as the putative transcription factor binding site.
In such a case the copy with the Highest GC content is used to calculate the transition mutations.
Ethylene production rates increased with increasing copy number, with the highest rate achieved in the strain containing five integrated copies in addition to expression from a medium-copy, broad-host range plasmid.
Comparing the CCC values of a 531 × 531 distance matrices analyzed before [ 14] using Pearson's correlation, indicated that KOG2671 represents the single copy protein with the highest correlation value of 0.96 (Additional file 2).
All the methods were correlated, strongly suggesting that they were all measuring copy number, with the highest correlation coefficient between PRT and the first principal component of the aCGH data.
Copy number varied, with the highest copy subfamily, EFT-3A, containing 97 full-length elements.
When combining the high amount of correctly folded and targeted protein in multi-copy transformants with the high cell densities obtained in bioreactor cultures, exceptional membrane protein yields could be achieved.
In its first week of release, it debuted at number one on the Billboard 200 with 404,000 copies sold, the highest first-week sales in Carey's career, until E=MC² opened with 463,000 in 2008.
It opened at number one on the Billboard 200 with 605,000 copies sold, the highest first-week sales of her career, and among the highest first-week sales by a female artist in history.
An allele with three copies of the 31-kb interval has intermediate resistance (Rhg1-a), whereas an allele with 10 copies confers the highest known level of resistance (Rhg1-b) (Cook et al. 2012).
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