In fact, we found that reducing the dose of the dl gene from 2 to 1 wild type copy strongly suppresses the neuropathological effects of the Aβ42 polypeptide.
Disruption of the rpf gene was not possible in M. luteus in the absence of a second functional copy, strongly suggesting essentiality of this protein for normal growth [ 17].
Therefore, the regain of egfr copies might strongly contribute to the survival and outgrowth of disseminated cancer cells at the metastatic site [ 31].
Bootstrap values are not strong for internal nodes, certainly because of the weak phylogenetic signal for these sequences (Table 2), but terminal nodes grouping the paralogous copies are strongly supported.
The degeneration of PMM-2 genes and the comparatively high mean evolutionary rate of these members indicate the occurrence of relaxed purifying selection in the evolution of PMM gene family in wheat and relatives, which may have affected PMM-2 copies more strongly than PMM-1 paralogs.
Reversely, embryonic lethality correlated with a higher transgene copy number, strongly suggesting that when the Cre is partly efficient, the GFP cassette is excised from multiple transgene copies, resulting in a tiar transgene expression above the threshold level compatible with embryonic survival.
Our results reveal a complex genomic architecture in the i(17q) breakpoint cluster region, characterized by large (∼38 49-kb ∼38 49-kbomic, low-copalindromic strongly suggesting that somatic rearrangements are not random events but rather reflect susceptibilities due to the genomic strepeats.
Hence, even though non-binomial distributions were rare in the three cell lines, they were sufficiently frequent to generate cells with a DM copy-number strongly deviating from the modal value of the cell population.
