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The most intuitive functional consequence of a change in genomic dose is a change in gene-expression levels (i.e. more copies imply higher expression, and vice versa).
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In addition, although each functional vector particle (1 transducing unit) carries two RNA copies implying a theoretical ratio of 0.5, in reality the TU/RNA ratio ranged between 0.0009 and 0.0832 (Table 1).
Besides, similar results in the codon usage pattern as well as the findings for divergence and ratio of nonsynonymous to synonymous substitutions were also revealed between paralogs and orthologs of actin copies, implying that actin copies were highly homologous within groups.
In addition, this fragment is located next to one ISAba6 copy implying that ampC gene has been disrupted during evolution of this strain.
But being expressed alongside the old copy implies increased dosage, which is frequently deleterious.
In addition to a few small indels, these three copies of the AMY1 gene are more than 99.9% identical in DNA sequence to one another and a similar sequence identity extends for a region of about 26.5 kb around each copy, implying that this corresponds to the underlying copy-variable repeat unit of AMY1.
Functional redundancy generated by multiple copies also implies periods of relaxed selection pressures, except if duplication itself is advantageous as it is the case, for instance, for a positive dose effect of copy number [ 11].
Variation in pI of our alpha tubulin copies may therefore imply variation in cellular function.
Well, firstly because the marketing copy often implies that women can't use normal stuff due to our being a bit stupid.
Hence the error and the missing sentence must have been introduced in separate copying steps, implying that none of the surviving manuscripts are closer than two removes from the original version.
In any case, the high frequency (34%) of tumours with increased LRIG1 gene copy number implies a positive selection for tumour cells with this genomic alteration.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com