Bionic and empty, it cribs liberally from Dead or Alive's 1985 hit "You Spin Me Round (Like a Record)" and sold a million digital copies faster than any other single to date.
The new mutations accumulated due to growth tend to be more deleterious due to their recency, but while less deleterious alleles increase in number of copies faster as the population grows, the very deleterious alleles are purged more effectively in this scenario.
Quite a few foreigners lost out to the hordes of Chinese entrepreneurs who copied fast and understood their customers better.
For comparison, also in the high-copy fast G1 mouse the onset of Golgi fragmentation at post-natal day 30 [ 27] coincides with the onset of ATF3 expression, signs of ER stress and microglia activation [ 48].
For one experiment we used paraffin embedded spinal cord tissue from 90 days old high copy (fast) G1 mice (carrying ~20 hSOD1-G93A transgene copy numbers, see above) crossed with mice deficient for the mitochondrial apoptotic pathway in the central nervous system, termed DKO mice.
There is substantial evidence of early activation of apoptotic pathways in SOD1-ALS mice [ 49, 50], and accordingly complete blockade of the mitochondrial apoptotic pathway through deletion of both BAX and BAK attenuated motor neuron loss and extended survival in high copy (fast) G1 mice [ 33].
We calculated δif and δis for the internal branch leading up to the slow copy and fast copy, respectively.
Present-day photocomposition machines use computers to make end-of-line (hyphenation and justification) and page design decisions automatically, thereby producing copy faster and cheaper than units that require operators to make end-of-line decisions.
Otherwise success can mean being copied faster than you can spell "EASYware".
In a quick-to-copy, fast-to-roll-out market like China's, the real competition is between giants like Baidu and Alibaba.
