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Loss of TopoII alpha gene copies contributed to the mRNA decrease in these cell lines.
It is hypothesized that the donor of chloroplast DNA is the maternal parent of Th. intermedium and that the different GBSSI variants represent homoeologous copies contributed to Th. intermedium by its putative progenitors.
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As full-length elements are the only elements capable of transposition, selection limiting the spread of full-length copies could reduce the transposition rate and the number of new nLTR-RT copies, contributing to the low copy number of most families.
For each consecutive site, the gene copy contributed to the gamete was sampled from the same chromosome or from the alternative one with probability (1 – c) or c, respectively, where c = 0.5 {1 – exp[−2L/(ns + nn − 1)]} represents the recombination fraction (Haldane 1919).
It relies on standard components from known suppliers and can be easily copied, contributing to its large footprint around the world.
Teleost-specific genome duplication (TGD) likely provided gene copies that contributed to evolutionary radiation and phenotypic diversification of teleost fishes.
However, these reports were not independently confirmed [ 8], with one notable exception where integrated virus-specific sequences were discovered in mice infected with lymphocytic choriomeningitis virus (LCMV), leading to the intriguing hypothesis that the integrated copies might contributed to the lifelong immunity of the survivor animals [ 9].
Increased gene copy number contributed to GEP overexpression in subset of HCC.
To investigate if TopoII alpha gene copy loss contributed to the mRNA decrease, fluorescence in situ hybridisation using a TopoII alpha-specific probe was performed.
These results suggest that 15 55% of the copies may have contributed to ISWen2 expansion during recent wRi evolution.
In four of the five cases, no mutations were present on all copies of the amplified segment, even allowing for the one patient where both parental copies of the locus contributed to the amplification.
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