There was no difference in locomotor response between male WT and KO or female WT, HET or KO mice when placed in a novel environment, nor any differences observed across genotype and sex when mice were tested on an accelerod (data not shown), indicating that KO mice have no gross motor coordination abnormalities or other motor impairments that might interfere with responses to novelty.
The impaired ability to sequence movements was the most frequent movement abnormality in schizophrenia patients: 67% of the patients had at least one mild impairment of movement sequencing as compared to a 33% incidence of sensory integration problems, and 13% of motor coordination abnormalities.
These factors are, however, linked significantly with the other NSS cluster-movement coordination abnormalities-which may reflect different neurobiology and etiology of individual movement abnormalities in schizophrenia.
Coordination abnormality, lower Mini Mental State Examination score, older age, vegetarian diet, and less participation in physical exercise were only significant in univariate analyses.
Coordination abnormality meant under or over shooting of a target and impaired timing or integration of muscle activity during finger-to-nose examination.
At the start of TMZ treatment he presented with a left-sided haemiplegia and facial nerve palsy, coordination and behavioural abnormalities and seizures, and required 1.5 mg kg−1 day−1 of prednisolone.
The Tc(Hsa21 1TybEmcf (Tc1) mouse contains a freely segregating, and near complete, copy of Hsa21 which is retained mosaically throughout the tissues of the mouse and exhibits a broad range of DS-like phenotypes, including craniofacial abnormalities, motor coordination deficits, and cognitive impairment.
To determine if the reduction in enzymatic capacity translated to a physical abnormality in coordination, heterozygous mice were tested by rotorod.
Tremors, lack of coordination, slurred speech, and sensory abnormalities are just a few of the hallmarks of mercury poisoning.
Long-term scans of activity in home cages were performed to determine abnormalities in motor coordination and circadian activity.
Transgenic mice with pan-neuronal expression of p.P56S VAPB develop progressive hyperactivity, deficit in motor coordination and balance, and gait abnormalities (Aliaga et al., 2013).
