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Therefore, our study reveals a novel and specific role for Sin1 in coordinating the activation of mTORC2 and mTORC1 to control B cell growth and metabolism.
We examined specific serum complement components in coordinating the activation of tumor suppressors p53 and WWOX (also named FOR or WOX1) and kinases ERK, JNK1 and STAT3 in human prostate DU145 cells.
These observations suggest that Rab9 may play a previously unappreciated role in the formation of lysosome-related organelles by coordinating the activation and inactivation of Rab32 and Rab38.
The 1.8 kb region preceding the UAS in the pho1 + promoter is required for Pi sensing, coordinating the activation by Pho7 and repression by Csk1 based on Pi availability.
This can be accomplished by spatially coordinating the activation of actomyosin contractility above basal force levels, which yields a significant force exchange between neighboring cells, or by spatially coordinating the de-activation of actomyosin contractility and/or cell matrix adhesion, which may increase the transduction range of basal force levels beyond one cell diameter.
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Tissue macrophages and their blood borne monocyte counterparts are activated by bacterial products such as endotoxin, and coordinate the activation of the adaptive immune response in the setting of infection by presenting foreign antigen to lymphocytes and secreting chemokines.
Neural adaptations to training can be defined as changes within the nervous system that allow a trainee to more fully activate prime movers in specific movements and to better coordinate the activation of all relevant muscles, thereby affecting a greater net force in the intended direction of movement [ 40].
Gauthier, N. C., Fardin, M. A., Roca-Cusachs, P. & Sheetz, M. P. Temporary increase in plasma membrane tension coordinates the activation of exocytosis and contraction during cell spreading.
Here we identify HOTTIP, a lincRNA transcribed from the 5' tip of the HOXA locus that coordinates the activation of several 5' HOXA genes in vivo.
The motor control mechanisms that are required to coordinate the activation of discrete functional elements of this muscle remain to be determined.
Site-specific PTM of these sliding clamps helps to coordinate the activation of specific pathways.
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