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Your finding that stress-activated Ypk1, an orthologue of the mammalian Sgk1 protein kinase, phosphorylates and stimulates the Lag1/Lac1 catalytic subunits of the ceramide synthase complex thus coordinating regulation of the sphingolipid biosynthesis pathway in response to stress is a significant advance and constitutes a very nice piece of work that merits publication in eLife.
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If we consider the profiles of flux associated with coordinate enzyme regulation and with single enzyme regulation, it is clear that the coordinate regulation provides a more robust strategy for regulating the pathway.
It has been proposed that bile acids regulate hepatic lipid homeostasis through the coordinate regulation of Fxr, Shp, Lxr and Srebp1c genes.
This suggests that CHD1 and H1 might regulate multiple immunity-related genes through their coordinate regulation of Dorsal expression.
To determine biologically coordinated regulation by any pair of TF or miRNA regulators, we utilized several measures for assessing the statistical interaction between the miRNA and TF variables.
Furthermore, myostatin may also be a transcriptionaly regulated by FoxO1 [ 53], possibly suggesting coordinate regulation of hypertrophy and myogenesis via multiple mechanisms including Fox01/myostatin signaling.
Development and homeostasis require coordinate regulation of neighbouring genes through a process termed locus control.
Fundamental to the process of mammalian development is the timed and coordinated regulation of gene expression.
Blattner, M. et al. SPOP Mutation drives prostate tumorigenesis in vivo through coordinate regulation of PI3K/mTOR and AR signaling.
Overall, the in-depth understanding of HOTAIR structure provides the first glimpse of coordinate regulation driven by modular features.
Meanwhile, the G-20's broader good intentions to coordinate regulation across borders are looking flaky, too.
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