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Gauthier, N. C., Fardin, M. A., Roca-Cusachs, P. & Sheetz, M. P. Temporary increase in plasma membrane tension coordinates the activation of exocytosis and contraction during cell spreading.
Here we identify HOTTIP, a lincRNA transcribed from the 5' tip of the HOXA locus that coordinates the activation of several 5' HOXA genes in vivo.
This could allow axons to avoid the extensive emission of secondary branches and/or favor the pruning of supernumerary filopodia in response to guidance cues as observed during development when axons retract in response to repellent-cues like Semaphorin 3A that coordinates the activation of Myosin II [38].
For instance, IKKi also phosphorylates interferon regulatory factor (IRF) and coordinates the activation of IRF and NF-κB after TLR ligation.
For example, HOTTIP (a lincRNA transcribed from the 5' end of the HOXA locus) coordinates the activation of several HOXA genes; chromatin looping brings HOTTIP close to its targets, and this drives H3K4 trimethylation and transcription [ 35].
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Tissue macrophages and their blood borne monocyte counterparts are activated by bacterial products such as endotoxin, and coordinate the activation of the adaptive immune response in the setting of infection by presenting foreign antigen to lymphocytes and secreting chemokines.
Neural adaptations to training can be defined as changes within the nervous system that allow a trainee to more fully activate prime movers in specific movements and to better coordinate the activation of all relevant muscles, thereby affecting a greater net force in the intended direction of movement [ 40].
Therefore, our study reveals a novel and specific role for Sin1 in coordinating the activation of mTORC2 and mTORC1 to control B cell growth and metabolism.
The motor control mechanisms that are required to coordinate the activation of discrete functional elements of this muscle remain to be determined.
Site-specific PTM of these sliding clamps helps to coordinate the activation of specific pathways.
We examined specific serum complement components in coordinating the activation of tumor suppressors p53 and WWOX (also named FOR or WOX1) and kinases ERK, JNK1 and STAT3 in human prostate DU145 cells.
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