Since Notch coordinates self-renewal program of early lymphoid progenitors, activating Notch1 mutations increase the self-renewal capacity of the LSC, resulting in their susceptibility to acquire and accumulate additional genetic abnormalities.
We detail in section 'Discrete control for coordinating self-sizing and Dvfs managers' the design of a coordination controller for the two managers and show how it is integrated within a management system in section 'Implementation'Implementation
In this context, partnerships take up meta-governance roles and coordinate self-organised collaborative governance processes while ensuring synergies and delivering on sustainability ambitions.
First, the light stimulation was stopped precisely at 48 hours post-injury; reliable wash-out of pharmacological inhibitors or inactivation of misexpressed genes cannot be done in this system, and these data demonstrated that hyperpolarization during the first 2 days is sufficient to induce the entire complex, highly coordinated, self-limiting 7-day cascade of tail rebuilding.
In both Le Corps (1969; "The Body") and Les Eclairs (1971; "The Flashes") Rolin investigates the time-space coordinates of self, body, and writing.
A multicomponent secretion system ensures the safe transport of the aggregation-prone curli subunits across the periplasm and outer membrane, and coordinates subunit self-assembly into surface-attached fibers.
The mean pressure distributions, when expressed in reduced coordinates, are self-similar and may be approximated by the pressure variation induced by an inviscid rotational vortex hovering above a flat surface in uniform smooth flow.
In fact, when genomewide genetic variation of European populations is projected down to a two-dimensional Principal Components Analysis plot, a surprising correlation with actual geographic coordinates of self-reported ancestry has been reported.
We apply our approach for coordinating the self-sizing and Dvfs managers for the management of a replicated-based system.
This paper presents an experimental evaluation of two representative slack redistribution policies for multitasking real-time control systems: "coordinated" vs. "self-triggered".
Therefore DIGME provides an ideal experimental system to understand the mechanical mechanisms coordinating the self-organized collective cancer invasion (Gjorevski et al. 2015).
