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By repeatedly viewing its targets over five years, it should get to know the brightest stars' coordinates down to an error of just seven micro-arcseconds.
By repeatedly viewing its targets, it should get to know the brightest stars' coordinates down to an error of just seven micro-arcseconds - an angle equivalent to a euro coin on the Moon being observed from Earth.
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The process of coordinated down-frequency regulation can be described as follows.
In contrast, a significant number of genes showed coordinate down-regulation, suggesting downstream involvement in common pathways.
A recent study reported a coordinate down-regulation of many genes involved in mitochondrial structure and function in several tissues[19].
These data suggest a feedback regulatory relationship between the sense and antisense RNA molecules; however, possible mechanisms why this coordinate down-regulation might occur are not known.
The transcriptional profile during later phases of immobilization also show the coordinate down-regulation of every bioenergetic pathway, but are also marked by a reduction in protein synthesis pathways and an increase in some components of proteolytic systems.
Coordinate down-regulation of a large set of lipid processing genes in AE skin could explain an impaired lipid balance previously observed in these patients, which may be a key factor underlying the cause of a disrupted skin barrier in AE patients.
Coordinate down-regulation was also seen for two mRNAs involved in kDNA replication: one of them, kDNA ligase alpha, is maximal in G1/S in T. brucei [ 61].
Microarray genes coding for structural myocardial proteins showed coordinated down-regulation in fish reared at 19°C compared to 14°C at both time points (Table 2), including different transcripts for myosin, actin and troponin.
Our results showing a coordinate down-regulation of ER molecular chaperones in response to PEG treatment fit quite well with this current model of coupling ER protein processing capacity to the rate of protein synthesis [ 67].
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