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The paper deals with the equivalence under coordinates change, of a discrete-time nonlinear multi output system to observer canonical forms.
Based on a linear discrete observer, a sampled-data output feedback controller is explicitly designed, in which a scaling gain is introduced by a new coordinates change of the system to dominate the nonlinearities.
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Since homeostatic plasticity coordinates changes of different cellular properties, over time it is expected to constrain these properties, limiting ways in which they can co-vary within the population of cells (O'Leary et al., 2013): for example, strong excitatory synaptic drive results in lower intrinsic excitability.
For example, the coordinate change of CDS-ID1 from mouse to human would be comparable to the HAR1 separation representing an evolutionary aspect from chimp to human.
At the expert center, the US medical expert moves a fictive probe, connected to a computer (no. 1) that sends the coordinate changes of this probe via an ISDN or satellite line to a second computer (no. 2), located at the isolated site, that applies them to the robotic arm holding the real echographic probe.
This method (ssGSEA) can identify coordinated changes of genes belonging to a gene set in a more sensitive way than other over-representation methods (more centered on individual genes) like the ones mentioned above, that could miss some signaling or biological pathways.
The coordinate changes of LINE-1 and HERV-K DNA methylation suggest that hypomethylation in urothelial cancer affects a variety of different retroelements to similar extents.
Extended phenotypes in ants induced by fungal infections are a complex example of behavioral manipulation requiring coordinated changes of host behavior and morphology.
(1) The one-sided OLS (ordinary least squares) test detects coordinated changes of genes in gene set in one direction, either up- or downregulation.
Coordinate changes of transcription and translation were detected for about 70 genes characterized by above-average transcript levels and translational efficiencies during exponential phase.
We further investigated whether the pancRNA/mRNA pairs exhibit coordinated changes of expression, and found that most of the upregulated pancRNA/mRNA pairs showed coordinated upregulation in 2-cell embryos (supplementary material Fig. S3).
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