In all these cases, the tissue dynamics is coherent, composed of local cell proliferation, and in the case of chick LS, coordinated cell migration [21].
In contrast, homeostatic chemokines, such as CCL19, CCL21 and CXCL12, are constitutively expressed in order to coordinate cell migration and development of the immune system [3].
The Rho GTPases, RhoA, Rac1 and Cdc42, are a class of proteins that are key regulators of the actin cytoskeleton in coordinating cell migration and cell-cell adhesion [15], [16].
A precise spatial and temporal control of Rac/Cdc42 activation at the plasma membrane is therefore required to coordinate cell migration.
Communication among limb epidermis, peripheral nerves, and mesenchyme coordinate cell migration, cell proliferation, and tissue patterning to generate a blastema, which will form missing limb structures.
How the activities of the numerous actin regulators known to operate in hemocytes are integrated to facilitate coordinated cell migration will doubtlessly be an important area to watch.
A very elegant study recently revealed a pregastrulation role for Dkk1 at E5.5 E6, when the initial proximal distal axis of the mouse embryo is converted to a p polarity, by a process involving coordinated cell migrations (Kimura-Yoshida et al., 2005).
Costa, G. et al. Asymmetric division coordinates collective cell migration in angiogenesis.
Functional characterization of a mutant EphA2 compromised in SHIP2 binding reveals two previously unrecognized functions of SHIP2 in suppressing ligand-induced activation of EphA2 and in promoting receptor coordinated chemotactic cell migration.
Here, we discuss how Rab11 and Moesin could cooperate to transfer forces from cell to cell in order to insure coordinated collective cell migration.
