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Lhx1 is initially expressed in the Spemann-Mangold organizer in Xenopus [19], a region that coordinates cell fate specification and axis formation [20], [21].
More specifically, it has been shown that miRNAs play critical roles in the survival and recovery from starvation-induced L1 diapause (Zhang et al. 2011) and that a feedback loop involving DAF-12 and let-7 family miRNA members coordinates cell fate decisions with starvation-induced dauer arrest (Bethke et al. 2009; Hammell et al. 2009; Karp and Ambros 2012).
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To establish and maintain organ structure and function, tissues need to balance stem cell proliferation and differentiation rates and coordinate cell fate with position.
His research focuses on understanding how epigenetic tags on DNA affect gene expression and coordinate cell fate and function, as well as on the role played by long noncoding RNAs and other RNA structures in biological regulation.
Chang's research focuses on understanding how small molecules attached to the DNA affect gene expression and coordinate cell fate and function, as well as on the role played by long noncoding RNAs and other RNA structures in biological regulation.
In mice a single stem cell population maintains the adult epidermis by coordinating cell fate and using existing tissue organization.
Hox proteins are well-established developmental regulators that coordinate cell fate and morphogenesis throughout embryogenesis.
However, technical challenges have impaired the study of the molecular interactions coordinating cell fate choice and cell-cycle progression.
In particular, a suite of intercellular signaling mechanisms, commonly referred to as developmental pathways, are used iteratively and combinatorially to coordinate cell fate and function during embryogenesis, as well as to control postnatal tissue homeostasis.
The growth of a metazoan body relies on a series of highly coordinated cell-fate decisions by stem cells which can undergo self-renewal, reversibly enter a quiescent state, or terminally commit to a cell specification program.
Currently, his work focuses on how Ras and PI3K activity are coordinated in cell fate control, and how signal processing is disregulated in cancer cells harboring mutations in these pathways.
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