Sentence examples for coordinates cell cycle from inspiring English sources

To understand the mechanism underlying this finding, we focused on the anaphase promoting complex (APC), the major regulatory complex that coordinates cell cycle progression and exit from mitosis [9], which was also the most statistically significant pathway found in our analysis (Fig. 3).

The DNA damage checkpoint signalling cascade sense damaged DNA and coordinates cell cycle arrest, DNA repair, and/or apoptosis.

KRIT1 negatively coordinates cell cycle also in mouse embryo fibroblasts (MEFs) by controlling FoxO-mediated downregulation of cyclin D1 and upregulation of p27Kip1 levels through the modulation of intracellular ROS levels [22].

This mechanism, requiring methylation of histone H3 and the Tudor domain of Rad9, regulates resection and appears to represent a strategy that coordinates cell cycle arrest with nuclease progression, thus limiting the amount of ssDNA generated during the cellular response to DNA damage.

Other studies identified some of the mechanisms coordinating cell cycle and differentiation decisions in the retina.

Furthermore, DSBs also elicit a checkpoint response, which coordinate cell cycle progression with DNA repair capacity (reviewed in [2] [4]).

Together, these data support that JNK2 prevents replicative stress by coordinating cell cycle progression and DNA damage repair mechanisms.

Following the phosphorylation of H2AX, repair proteins such as the MRN complex, ATM, and 53BP1 coordinate cell cycle arrest, DNA repair and apoptosis [3].

In addition to their well-established role as microtubule organizers, centrosomes serve as important scaffolds for the integration of multiple signaling pathways that coordinate cell cycle progression [13].

Together these results suggest that Rb is required to coordinate cell cycle exit with survival during the onset of differentiation, but not for actively stimulating the differentiation program.

Wnt signaling can coordinate cell cycle progression by regulating modulators of cell cycle checkpoints [ 31].