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Lhx1 is initially expressed in the Spemann-Mangold organizer in Xenopus [19], a region that coordinates cell fate specification and axis formation [20], [21].
Together with Tap42p, Sit4p is known for its participation in the TOR pathway, which senses nutrient availability and coordinates cell growth [45].
Thus, p53 serves as a metabolite sensor and, depending upon cell type and the strength of the stress, coordinates cell survival, resulting in reversible cell-cycle arrest, cellular senescence, or reduced cell viability [11], [14].
Based on these observations and the results presented here, we propose that mutual linkages between Runx, Wnt, and Cyclin D activities constitute an ancient control circuitry (Fig. 6) that is a conserved module within the regulatory network that coordinates cell proliferation with patterning and differentiation in animal development.
We are currently applying the barcode approach to interrogation of cell size phenotypes in the context of different nutrient sources, ploidy conditions, genetic backgrounds and in the presence of various chemical reagents as well as 'perturbagens' to systematically decipher the global network that coordinates cell growth and division.
To understand the mechanism underlying this finding, we focused on the anaphase promoting complex (APC), the major regulatory complex that coordinates cell cycle progression and exit from mitosis [9], which was also the most statistically significant pathway found in our analysis (Fig. 3).
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We suggest that PRC coordinates cell-cycle phases with mitochondrial metabolism through both positive and negative interactions with CREB1 and NRF-2 transcription factors.
To identify the genes acting within a regulatory network that coordinates cell-cycle progression with development, we conducted a genome-wide, reverse genetic screen.
In mice a single stem cell population maintains the adult epidermis by coordinating cell fate and using existing tissue organization.
The need to define 'baseline stability' poses additional challenges related to the need to coordinate cell administration with the bone marrow transplantation laboratory.
where C denotes the CoMP set and (hat {w}_{j}) is selected precoding weight at the jth coordinating cell based on a given precoding method.
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CEO of Professional Science Editing for Scientists @ prosciediting.com