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Moreover, our data indicate that PRL/Jak2 coordinates both of these cellular events through limiting the mitogen activated protein kinase (Erk1/2) pathway.
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We therefore asked if JAK2 signaling coordinates both the posttranslational modification of histones and the concomitant binding of STAT5 to its target DNA.
Tissue-specific GATA-type transcription factors elt-2 and elt-3 play a major role in coordinating both of these gene expression programs and are required for the response to osmotic stress.
These results reveal that MDC1 coordinates both dephosphorylation of pTyr142 and phosphorylation of Ser139 of H2AX on the sex chromosomes during meiosis, and suggest the possibility that another kinase mediates pTyr142.
Interestingly, in our structures of catalytically competent cleaved and resealed DNA states, a single ion at each scissile DNA site coordinates both sets of reactive DNA groups.
Consistently, Asp394 in GltPh coordinates both the amino group of the bound substrate and Tl+ in the Ct site.
This data reveals new classifications of processes by which HR activities are developed, implemented and coordinated, both in terms of who is involved and how these processes are carried out.
β-Arrestins coordinate both phosphorylation of receptors and the rate of cAMP degradation by phosphodiesterases [ 85].
FruM therefore specifies the male form of the circuit switch, coordinating both the connection of aSP-f neurons to, and the disconnection of aSP-g neurons from, pheromone input.
Together these proteins coordinate both the repression of epithelial related genes and activation of mesenchymal genes.
By studying how the embryos coordinated both the secretion of the enzyme and the body movements, the researchers hope to better understand how the frogs and other animals are able to respond so quickly to threats.
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