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High scores indicate significantly coordinated up- or down-regulation.
Thus, the analyzed genes appear to follow a pattern of more or less coordinated up- or down-regulation of both strands in parallel.
The molecular composition of choroidal TJs is regulated during development, as exemplified by the coordinated up– or down regulation of specific pore forming and tightening claudins that make up the core of the junctional complex [ 15].
Evidence of homoeolog-specific coordinated up- and down-regulation of several functional gene categories, including those involved in protein synthesis and photosynthesis processes, suggests the co-evolution of cis- and trans-regulators.
To test for functional relatedness of the genes populating these clusters, we examined gene ontology enrichment within several sub-clusters that exhibited marked patterns of coordinated up- or down-regulation specific to single developmental stages.
Likewise, the clustering of peroxiredoxin isoforms in the second principal component indicates that these proteins similarly contribute to the overall variance of the dataset, and likely reflect coordinated up- and down-regulation across the cell lines.
Similar(47)
Interestingly, we also found significantly increased and coordinated up-regulation of COL1A1 and COL1A2 in the tumor tissue, both of which are important in blood vessel development.
These limited challenges had no significant effect on the expression pattern of the gene encoding β-casein but caused coordinated up-regulation of a number of cytokines and chemokines involved in pro-inflammatory responses.
Spherical harmonics expansion is then made in SM coordinates up to degree 2 for the ring current, in Geocentric Solar Magnetospheric (GSM) coordinates up to degree 2 and order 0 for magnetopause and magnetotail currents (Olsen et al. 2014).
With new IT technologies, the organization can coordinate up and down the hierarchy more quickly and with more detail.
We could show, that MT1 has the ability to coordinate up to five Zn2+ or Cd2+ ions and even higher amounts of Hg2+.
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