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Here, we first coordinated the expression of all genes of the mevalonate (MEV) pathway from Saccharomyces cerevisiae using the tunable intergenic regions (TIGRs), and then dynamically regulated the TIGR-mediated MEV pathway to prevent the accumulation of toxic metabolites by using IPP/FPP-responsive promoter.
MAC coordinated the expression assays, collaborated with data interpretation and revised the manuscript.
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According to a self-organization model, highly expressed master genes can form a transcription hub to coordinate the expression of many other genes [ 2].
To maintain homeostasis, cells need to coordinate the expression of their genes.
Collectively, these studies indicate that cells possess a mechanism that coordinates the expression of genes that are involved in common functional responses.
This calibration occurs through setting of response thresholds in the regulatory mechanisms that coordinate the expression and use of trait-specific gene products and environmental elements that build alternative phenotypes.
Quorum sensing is a mechanism in which bacteria coordinate the expression of certain genes in response to their population density by producing, releasing and detecting signal molecules called autoinducers.
The mechanism that coordinates the expression of these proteins during early neuronal development remains largely unexplained.
These suggest that another regulator may coordinate the expression of conidiation-specific genes.
An important issue now is to understand how insulin coordinates the expression of all these genes.
The NF-κB family of transcription factors is coordinating the expression of a wide variety of genes [1].
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