The mechanisms by which Grb2 regulates endocytosis of RTKs is not fully understood, and we can hypothesize that HD-PTP and Grb2 work together, probably with other proteins as well, to assemble and/or coordinate the assembly of endosome-associated protein complexes essential for vesicle biogenesis and protein sorting.
The man in charge of coordinating the assembly of the reactor is Ken Blackler.
Here, we review advances in our understanding of how these mechanisms act to shape structure and function at the single cell level, to coordinate the assembly of cell populations, and to define their specific circuitry.
According to this model, the main role of SRP would be to coordinate the assembly on the translocon, of membrane-bound ribosomes translating membrane proteins.
The regulatory steps that coordinate the assembly of adhesion plaques into functional attachment structures capable of enduring and transmitting mechanical stress are largely undefined.
This peptide, which lacks the two cysteine residues conserved across all other chaplin domains, has orthologues in other Streptomyces species and is thought to coordinate the assembly of the other chaplins into the pair-wise aligned rodlet structures that comprise the hydrophobic coat.
Considering the resources devoted to this study and one earlier investigation [11], we conclude that a task force of ten scientists could, within a decade, coordinate the assembly of a DNA barcode reference library for the global Lepidopteran fauna, including the 155,000 described species [29] and the anticipated number of undescribed species which may raise the total up to 500,000 species [30].
Glia-derived factors coordinate the assembly presynaptic structures and the precise apposition of presynaptic and postsynaptic specializations.
Clearly, premature export of immature cofactor-containing enzymes must be avoided, and systems have been unearthed that coordinate the assembly and export events.
Thus, it is likely that Mcm2-7 coordinathe the assembly of other chromatin-associated proteins that play important roles in the cell-division cycle.
