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Indeed, coordinated silencing of the Pcdh family of genes was seen in cancer [34].
The coordinated silencing of all but one VAR gene is the crux of prolonged malaria infections and the slowly developing and incomplete immunity to the pathogen.
An elaborate and poorly understood mechanism of coordinated silencing of the VAR genes is combined with rare epigenetic switches to other variants to confer an ever-shifting antigenic makeup.
This posttranslational modification pushes the local chromatin structure towards a transcriptionally repressive state and its proper establishment is essential to the coordinated silencing of genes through-out mammalian development (Boyer et al. 2006; Wang et al. 2004).
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Using a dual optogenetic/photopharmacological strategy, silencing of hubs abolished coordinated islet responses to glucose, whereas specific stimulation restored communication patterns.
Here we report the high prevalence of coordinated epigenetic silencing at 2q14.2 in most if not all colorectal carcinomas.
A recent publication has described step-by-step methylation silencing of the fas gene, suggesting coordinated action of 28 RAS-related epigenetic silencing effectors [ 17] that employ a well-organized signal transduction pathway.
We postulated that the presence of PRC2-EZH1 conplex on active promoters, and not on repressed loci, could be explained by a novel role for PcG to control prompt response to specific to stress conditions and silencing of tissue specific active genes in a global coordinated manner.
But there is something compelling about the spectacle of this mourning parade — the coordinated chain swings that undo the silence of a wintry Tehran afternoon, in line with the rhythm of a Yamaha bass drum that shatters it.
Therefore, it is proposed that under acidic or standard laboratory growth conditions, expression of LEE and non-LEE-encoded effectors is silenced via the coordinated actions of cAMP, GadE and Hfq systems.
Pro-democracy leaders in Hong Kong have accused Beijing of political thuggery after a local bookseller claimed he had been kidnapped by Chinese "special forces" as part of a coordinated bid to silence criticism of China's Communist leadership.
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