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Similarly, adaptive responses which involve interactions between opposing changes can promote coordinated segregation into two anti-correlated subpopulations.
The likely association between the chromosome and specific components of the TO, supported by a recent report by Hatchel and Balish [6], would certainly facilitate a coordinated segregation of both structures.
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A mitosis-specific structure that has recently been focused on for development into a drug target is the kinetochore, the protein complex that coordinates chromosome segregation.
Our data suggests that Plk1 controls anaphase spindle elongation and contractile ring assembly to coordinate chromosome segregation with cytokinesis in animal cells.
Our results demonstrate that Plk1 coordinates chromosome segregation with cytokinesis through its dual control of anaphase B and contractile ring assembly.
Therefore, centromeres orchestrate opposing mitotic processes and coordinate chromosome segregation in mitosis.
The microtubule system, a major component of the cytoskeleton, was identified as a suitable target for cancer therapy, primarily based on their biological importance in coordinating chromosome segregation during mitosis.
These asexual forms (e.g., merozoites, tachyzoites) have two microtubule populations; spindle microtubules coordinate chromosome segregation during mitosis, and subpellicular microtubules subtend the pellicle to impose an elongated cell shape and cell polarity (27– 27).
In trypanosomatids, cell division involves morphological changes and requires coordinated replication and segregation of the nucleus, kinetoplast and flagellum.
This provides a mechanism by which the onset of chromosome segregation is coordinated with mitotic exit.
This finding reinforces the central role that Pex3 plays in coordinating peroxisome formation, segregation and breakdown.
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