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The data strongly suggest that this is part of a coordinated reprogramming of host cell functions which leads to improved microbial fitness by promoting intracellular survival, replication, and spread.
The data suggest that evolutionary changes in lifespan in mammals are associated with coordinated reprogramming of expression levels at the genomewide scale rather than with changes in expression of individual genes.
Lindholm, M. E. et al. An integrative analysis reveals coordinated reprogramming of the epigenome and the transcriptome in human skeletal muscle after training.
Simultaneous changes in transcript abundance indicate that there is coordinated reprogramming of gene expression during fruit development and at the onset of ripening in both climacteric and non-climacteric fruits.
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Coordinated reprogramming would allow the cell to acquire the capabilities for malignant growth.
These simple parametrizations of the data reveal frequently co-occurring marks, which could potentially be read by multivalent chromatin complexes, or represent differential signatures of coordinated epigenetic reprogramming.
Direct reprogramming of diverse mouse cell types.
Direct reprogramming of diverse human cell types.
Shufaro, Y. et al. Reprogramming of DNA replication timing.
Direct lineage reprogramming of post-mitotic callosal neurons into corticofugal neurons in vivo.
"It represents the complete reprogramming of an organism using only a chemical entity," Dr. Ebright said.
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