Sentence examples for coordinated repression of from inspiring English sources
The rapid and coordinated repression of histones and M/G1-specific transcripts cannot be explained by cell cycle arrest, and suggested that there are additional signaling pathways that directly repress these genes in cells under genotoxic stress.
We provide evidence that derangement of CRABP2 function is sufficient to trigger the coordinated repression of the RARα direct target RARβ2, and two RARβ2 downstream targets, CRBP1 and CYP26A1.
However, many reports have shown the different members of the miR-200 family have similar effects on epithelial-mesenchymal transition (e.g. through the coordinated repression of Zeb proteins) [9], [10], [11], [12].
The coordinated repression of OSM and CISH that we showed in T cells following IL-2 withdrawal is consistent with these observations.
A change of expression of 109 genes was observed, including the coordinated repression of a set of 54 genes mostly involved in cell cycle progress.
The coordinated repression of genes are likely to contribute to survival by conserving energy and precursors under nutrient-limiting conditions and/or minimizing expression of potential antigens.
Interestingly, the coordinated repression capability of PAI-1 by miR-143 and 145 is an immediate consequence of the two spatially distinct target sites.
In neuronal disease, coordinated repression and expression of large chromosomal regions was found in caudate nucleus and whole blood [ 52].
Strikingly, most of them are genetic determinants of cell-cycle progression or suppression of senescence, suggesting that their coordinated repression mediates cellular responses to oxidative stress.
We conclude that genes in LRES regions are plastically regulated in cell differentiation and hyperproliferation, but are constrained to a coordinated repression by abolishing boundaries and the autonomous regulation of chromatin domains in cancer cells.
Despite our data supporting a notion that estrogen mediates epigenetic repression of the MT1 gene cluster in MCF7 cells, the underlying mechanism of what triggers this long-range coordinated repression process remains obscured.
