Sentence examples for coordinated reduction of from inspiring English sources

Therefore, the coordinated reduction of all of these genes after QKI-7 silencing suggests a regulatory effect of this splice variant in the IFN pathway in astrocytes.

A well known consequence of sepsis is the rapid and debilitating loss of skeletal muscle mass, which appears the result of a coordinated reduction of muscle protein synthesis together with an enhancement of proteasomal mediated muscle protein breakdown [1], [2].

The UPR is a network of signal transduction pathways that regulate the coordinated reduction of client protein load into the ER and the expansion of the ER folding capacity, thereby ensuring that the organelle remains in homeostasis [ 1].

Coordinated reduction of transcription of genes involved in amino acid catabolism suggests redirection of amino acids from catabolic pathways to protein biosynthesis.

Among those genes are yibK and rimM, encoding rRNA methylases and fusA and lepA, encoding translation factors, which further underlines the fact that depletion of 6S RNA results in a coordinated reduction of the components necessary for active translation.

In fact, retention of gene duplicates may be facilitated by coordinated reduction of expression levels, rendering both copies necessary to fulfill the biological role of the ancestral gene whereas creating redundancy at the level of their molecular function (Qian et al. 2010).

Figure 5(C) shows coordinated reduction in the transcription of the ribosome complex, the RNA polymerase complex (I/III), and the M-POL II complex in a subset of stress conditions (outlined rectangle).

It can be speculated that at the onset of lactation the essential cellular signaling systems are attenuated such that t10, c12-CLA is unable to elicit the coordinated reduction in the expression of genes for key lipogenic enzymes.

Only in low P treated leaves, a coordinated reduction in transcripts for ribosomal proteins was observed indicating general repression of protein synthesis under P starvation.

This is necessary, since the number of the resulting equations of motion can be so high that the classical coordinate reduction methods become inefficient to apply.

Each iron atom coordinates the reduction of methenyl-H4MPT and oxidation of H2 while bound to both Hmd and a cofactor molecule [ 8, 9].