The inclusion or removal of these SLiMs can switch the subcellular localisation of an isoform, promote cooperative associations, refine the affinity of an interaction, coordinate phase transitions within the cell, and even create isoforms of opposing function.
Phosphorylation-driven ubiquitination through the SCF pathway and subsequent proteasomal degradation have been considered as a biochemical switch crucial for coordinating phase changes during the cell cycle [6], [7].
In conclusion, our results provide the first indication of a potential mechanism by which neighbouring cells in the PSM might communicate and coordinate phase differences in a periodic manner.
These data support a model where the SCN shell coordinates phase at the system level, but yet the integrated function of the SCN network is necessary for maintaining high amplitude rhythms in downstream tissues.
As well as walking the patient through, the technology could be designed to help patients and carers coordinate phases of treatment and remind them of steps to be performed.
NE established the PTBGS cohort, performed assessments in phase 1 and has coordinated all phases.
This 8-coordinate phase is favored over 1 at higher temperature (200°C) for Er and favored over 2 at lower temperatures (160°C) for Tm.
ASdA conceived the design of the study, carried out the cell cultures, performed quantitative real-time PCR, coordinated and trained others to perform the experiments, participated in statistical analysis, and coordinated all phases of manuscript writing.
ASd'A conceived the design of the study, carried out the cell cultures, performed Q-RT-PCR, coordinated and trained others to perform the experiments, participated in statistical analysis and coordinated all phases of manuscript writing.
JL coordinated all phases of this project and drafted the initial manuscript.
In the tetrahedrally coordinated β phases, the same mixing is not achievable.
