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DOI: http://dx.doi.org/10.7554/eLife.05608.018 Our results have profound implications for current models of cardiac EC coupling as they provide an answer to a long-standing question in the field: What are the mechanisms that allow the simultaneous, coordinated opening of multiple CaV1.2 channels near the jSR?
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TCF-1 was further required for the accessibility of these regulatory elements and at the single-cell level, it dictated a coordinate opening of chromatin in T cells.
It is a focal point of the London art calendar, with museums and galleries coordinating openings of major shows around the fair.
If all the sexual health services in one geographical area worked better together and were more sensibly commissioned, we could coordinate opening hours and access and make economies of scale.
Gallerists are friendly, sending each other visitors and banding together to coordinate openings and art walks.
The city helped coordinate that opening of an emergency shelter that can hold 150 people.
Italian entrepreneur Marco Balich, who coordinated the opening ceremony of the 2006 Winter Olympics, held in Turin, was its producer and director, with "music moments and stage actions" were developed by the choreography director Doug Jack.
Alternating access within the POT family is physiologically driven by the proton electrochemical gradient, with defined conformational states stabilised through conserved pairs of salt bridges that act to coordinate the opening and closing of the intracellular and extracellular gates (Newstead, 2014).
The enzyme employs a duplex strand passage mechanism that requires coordinating the opening and closing of three protein "gates": the N-gate, DNA-gate, and Exit-gate.
Ms. Cisero said she has tried everything to keep Lewis under control, including force-feeding him Prozac and coordinating the opening and closing of doors with her boyfriend whenever they enter and leave the house.
The diurnal cycle also coordinates the opening and closing of stomata, affecting transpiration and changing the water potential in leaves.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com