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In conclusion, our study suggests the existence of a biologically coordinated mechanism of E-cadherin and sLex expression (i.e. molecular plasticity) essential for tumor establishment and metastatic progression.
These observations not only provide a potential linkage between EBV miRNAs and human malignancy but also suggest a highly coordinated mechanism through which EBV miRNAs may mimic or compete with human miRNAs to affect cellular functions.
Our results in these two comparative models (canine and human) suggest the existence of a biologically coordinated mechanism of E-cadherin and sLex expression (i.e. molecular plasticity) essential for tumor establishment and metastatic progression.
In both DR and AL conditions, the changes in network connectivity occurred in a modular, nonlinear fashion, suggesting a biologically coordinated mechanism.
Additionally, we observed that genes with higher transcriptional noise driven by promoter sequence content are targeted by more miRNAs compared to transcript with small noise level, suggesting the existence of coupled or coordinated mechanism for transcriptional and post transcriptional regulation.
"We want a coordinated mechanism, where member states need to cooperate and coordinate between themselves to avoid a patchwork of different times in the EU," she said.
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Machines for container glass forming are in themselves multi-axis machines with a lot of different coordinated mechanisms.
Recommendations for the UNICEF/DFID partnership Diversified and coordinated mechanisms to ensure a good dialogue with DFID should be established, with the PFO retaining its prominent role.
Our results imply that Dlx5 and Dlx6 control upper and lower jaw morphogenesis through different coordinated mechanisms to generate functional, articulated jaws.
Report Part 2 Recommendations for the UNICEF/DFID partnership Diversified and coordinated mechanisms to ensure a good dialogue with DFID should be established, with the PFO retaining its prominent role.
The module attempts to identify parts of common and biologically coordinated mechanisms or processes that govern coherent cellular outcomes and that could be characterized by the identified groups of preferential interactions.
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