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Reconstitution of MAPK pathways revealed that this LT-induced phenotype was primarily dependent on the coordinated loss of MKK1 and MKK2 signaling.
We previously examined whether loss of mitochondrial calcium was responsible for mitochondrial hyperpolarization [39], and demonstrated there is a coordinated loss of mitochondrial calcium with membrane hyperpolarization (Figure 5 in Ref. 39).
Accordingly, our data suggest a coordinated loss of miR-143/-145 expression as an early event in bladder carcinogenesis.
Of these, FOG-1 was shown to be required for the coordinated loss of GM priming and acquisition of Mk/E priming associated with preMegE formation.
A coordinated loss of syndecan-1 and E-cadherin has been documented in many epithelial malignancies compared to their benign counterparts.
This correlated on GO analysis to the coordinated loss of proteins in ECM-sandwich culture that comprise key liver metabolic functions such as "glycolysis," "xenobiotic metabolic process," and "alcohol metabolic process"; accompanied by an increase in structural proteins that map to the "muscle structure development" GO term (Fig. 7).
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The consecutive maturation stages from pre-B cells to mature B cells could be monitored by the coordinated acquisition and loss of leukocyte differentiation antigens.
After the trial showed positive results, patients suffering from debilitating symptoms of the disease -- including rigidity, a loss of coordinated movements and tremors -- suddenly had a drug that could help them resume many aspects of their earlier lives.
As shown in Fig. 1d, before the decomposition, continuous weight loss corresponds to the loss of coordinated solvent or the free H2O molecules.
As above, autonomic dysreflexia is a condition resulting from the loss of coordinated autonomic responses to demands on the heart rate and vascular tone.
The thermal decomposition of all the complexes occurs in three steps, starting with the removal of the coordinated solvent, followed by loss of the S-allyl group and finally the residual ligand fragment.
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