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Embryonic organ development is contingent on complex coordinated interactions of multiple transcription factors that regulate the expression of selected downstream target genes.
Coordinated interactions of the TFs influence surfactant homeostasis and regulate lung function at birth.
Biosynthesis of hepatic VLDL is critically dependent on the coordinated interactions of apolipoprotein B (apoB) and MTTP [ 72].
Depression is considered to be related to failure of the coordinated interactions of the dorsal and ventral compartment [ 37- 39].
This recruitment requires the coordinated interactions of Saw1 with the nuclease, the flap DNA, and upstream SSA factors (Li et al., 2008, 2013).
HIV entry into host cells requires coordinated interactions of the envelope glycoprotein gp120 with the CD4 receptor and with one of the chemokine receptors, CCR5 or CXCR4.
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Eukaryotic genes are transcriptionally regulated by the coordinated interaction of multiple protein factors that interact with discrete binding sites and with each other [ 20].
A similar paradigm has recently been proposed from studies on the regulation of DNMT1 protein stability through the coordinated interaction of an array of DNMT1-associated proteins, such as UHRF1, Tip60 (Tat-interactive protein) and HAUS (herpes virus-associated ubiquitin specific protease) [ 40- 42].
Just as the overall integrity and function of muscle cells does not depend on a single protein, but rather on the coordinated interaction of several proteins, the structural weakening of muscle cells during postmortem aging also must not depend on the degradation of a single myofibrillar or other cytoskeletal protein.
The immune response to pathogens requires the coordinated interaction of multiple cells, and the presence of different cell populations; thus, the cross-talk between populations may be more representative of in vivo functioning than are the findings from isolated cell populations.
It requires coordinated interaction of cardiac ion channels and contractile proteins.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com