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We observed coordinated increases in the expression levels of these four genes in the brain of the schizophrenic subjects.
Firstly, coordinated increases in levels of most AAs occurred in both genotypes at most time points during the chilling stress with the most dramatic increase synchronized the maximum difference in CT between LTH and IR29 during the chilling stress.
We establish that p43 expression induces profound and coordinated increases in mitochondrial activity, mitochondrial biogenesis, leading to a shift toward slow oxidative fibers.
Together these data demonstrate that TGF-β inhibitors drive functionally significant and coordinated increases in trabecular bone mass, mineral concentration and bone matrix material properties.
The overall levels of both EGR2 and MeCP2 showed gradual, coordinated increases in postnatal brain with age (Fig. 3B).
Increased ONOO− production occurs as a consequence of temporally and spatially coordinated increases in NO and O2−.
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By simply altering facX expression levels in a given cellular framework, we could simulate the generation of a new OC and SCD, which coordinated increase in size when facX is further upregulated (see Fig. S5 and Text S5).
Overall these results demonstrate that exercise training brings about a subtle but coordinated increase in the basal level of gene expression of a wide array of genes involved in energy production and metabolism.
Overall these results demonstrate that β-cell mass expansion in the context of obesity brings about a subtle, but coordinated increase in the basal level of a wide array of genes involved in the inflammatory and autoimmune response of ob/ob islets that does not occur in PPARγ2-ablated POKO islets.
The present observation that there is coordination of Myc protein expression with amino acid uptake thus reveals a mechanism that would ensure that T cells coordinate increases in glucose and glutamine and iron metabolism to match the biosynthetic demands associated with the immune activation of T cells.
ERRγ overexpression in mouse skeletal muscles results in a subsequent coordinate increase in mitochondrial function, in part, through increased TCA cycle activity, larger mitochondria and improved oxidative capacity52,56.
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