Sentence examples for coordinated in the regulation of from inspiring English sources

Genomic structure can explain how seemingly distant regulatory elements are coordinated in the regulation of gene expression but regions of open chromatin including enhancer and promoter regions are a defining feature of the regulatory genome.

Dysfunction or decrease of the stem cell pools is typical of physiological and pathological aging; it would be therefore interesting to determine how these two protein degradation pathways are coordinated in the regulation of stem cell homeostasis, and how the dysregulation of autophagy in stem cells is linked to aging and degenerative diseases.

In summary, we observed a developmentally coordinated switch in the regulation of Lef1 isoform composition, with increased inclusion of both exons 6 and 11, and also downregulation at the protein level.

This network result suggests that HAT22 may be involved in coordinating the regulation of the target genes in the three related metabolic processes "amino acid metabolism", "C-compound/carbohydrate metabolism" and "glycolysis/gluconeogenesis" [see Additional file 7].

In this case, TS may be involved in coordinating the regulation of expression and/or function of cellular growth and proliferation and it is conceivable that TS may play an essential role as a regulator of cell cycle related events.

CAS siderophore assays clearly demonstrated that the Δ so2426 mutant was deficient in siderophore production compared to wild-type MR-1 cultures in the presence and absence of chromate, indicating that SO2426 plays a positive role in coordinating the regulation of siderophore-dependent Fe uptake mechanisms in S. oneidensis.

During development, cell cycle progression must be coordinated with the regulation of cell specification and differentiation.

Our study reports a novel type of histone modification crosstalk between methylated H3K4 and acetylated H3K14, that may result in coordinating the regulation of gene transcription.

The plant growth regulator (PGR) auxin, the predominant form of which is indole-3-acetic acid (IAA), is a major coordinating signal in the regulation of plant development, with key functions in many processes including embryo formation [ 24, 25].

As has been observed in prior studies, this probably reflects the advantage of having genes in the same strand in order to coordinate the regulation of genes in operons [ 2].

However, by manipulating Erk activity or the Erk phosphorylation sites in Eps8, we demonstrate that Erk-mediated phosphorylation of S624 and T628 not only down-regulates the capping activity of Eps8 as shown previously (Menna et al., 2009), but may in fact coordinate the regulation of Eps8 capping and bundling activities.