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Therefore, CEACAM1 seems to be an attractive receptor for pathogens to infect cells and simultaneously disrupt well coordinated immune responses.
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Dendritic cells (DCs) are central players in coordinating immune responses, both innate and adaptive.
In general, dendritic cells coordinate immune responses to microenvironmental anomalies (i.e., infection and tissue damage) and orchestrate tolerance to self (4).
CD40, a member of the tumour necrosis factor receptor (TNFR) superfamily, and its ligand (CD40L/CD154) have a central role in coordinating immune responses and can mediate antiviral and antitumour effects.
Many of the genes involved in disease susceptibility are major players in coordinating immune response.
CC chemokine receptor proteins (CCR1 through CCR10) are seven-transmembrane G-protein coupled receptors whose signaling pathways are known for their important roles coordinating immune system responses through targeted trafficking of white blood cells.
Breech of the epithelial barrier by bacteria would necessitate a response by the host to the invading microbe and Nod2 has a recognised role in coordinating innate immune responses to intracellular bacteria.
Associated with an extensive range of transcription factors, the analysis suggests that PML bodies coordinate regulatory immune responses.
Thus, N1-polarized neutrophils have the potential to kill cancer cells and inhibit tumor growth [ 22- 24] as well as coordinate adaptive immune responses through interactions with dendritic cells [ 25].
CKT, CRG and HDD coordinated the Immune Response Annotation Group.
This review discusses the role of DC in initiating and coordinating the immune response against cancer, the ability of neuroblastoma to induce DC dysregulation at multiple levels by inhibiting DC maturation and function, and the current vaccine strategies being designed to employ the unique ability of DC to promote neuroblastoma regression.
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