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Therefore, Toll activation leads to a coordinated immune response that comprises both cellular and humoral immunity [ 38].
In this case, the lateral transfer of only a few molecules can fulfill important roles in a coordinated immune response.
Microbial pathogens represent an immediate threat to survival, and this requires a vigorous and coordinated immune response in defense of the viability of the host [ 5].
For example, where there is a dense tumour inflammatory cell infiltrate, the presence of a variety of inflammatory cell types is likely to reflect the activity of a coordinated immune response.
First, we will briefly summarize the very complex signalling events occurring during TCR-mediated T-cell activation, which leads to a perfectly coordinated immune response and is essential for understanding the age-related changes that may later lead to deregulated immune responses.
Taken together, these results would indicate that the majority of patients with primary operable invasive ductal breast cancer have evidence of a high-grade inflammatory cell infiltrate and that components of this response, representing a coordinated immune response, have prognostic value superior to that of tumour-based factors.
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Therefore, CEACAM1 seems to be an attractive receptor for pathogens to infect cells and simultaneously disrupt well coordinated immune responses.
Many of the genes involved in disease susceptibility are major players in coordinating immune response.
Dendritic cells (DCs) are central players in coordinating immune responses, both innate and adaptive.
The human immune system produces dozens of cytokines, with names like "interleukin-1" and "interferon-gamma," which act as messengers between cells, coordinating immune responses such as inflammation.
In general, dendritic cells coordinate immune responses to microenvironmental anomalies (i.e., infection and tissue damage) and orchestrate tolerance to self (4).
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