Sentence examples for coordinated deregulation of from inspiring English sources

In summary, there was no compelling signature at the level of gene expression of a coordinated deregulation of apoptotic pathways underpinning in vitro GC resistance.

Conversely, knocking down SLIT2 expression increased cell migration and reduced cell adhesion through coordinated deregulation of β-catenin and E-cadherin/SNAI1 in the AKT/GSK3β/βTrCP pathway [ 102].

Probably most importantly, does the coordinated deregulation of EMT and senescence reflect only a "collateral effect", or instead, are there mechanistic links that tie these two processes together [ 54]?

The expression levels of several genes flanking the FOXO1A locus were similar in each of the CNS-PNET cell lines, suggesting that a generalised chromatin restructuring and/or coordinated deregulation of genes in the region of 13q14.11 is unlikely to explain the aberrant FOXO1A expression observed in the PER-453 cell line.

Notably, we observed reciprocal expression changes in the enzymes sphingosine kinase 2 (SPHK2) and sphingosine-1-phosphate phosphatase 1 (SGPP1) as well as changes in the expression of acid ceramidase (ASAH1), sphingomyelin synthase 1 (SGMS1) and sphingomyelin phosphodiesterase 1 (suggestingggesting a coordinated deregulation of ceramide biosynthesis (Fig.  5A).

Finally, the co-expression of CITED2 co-transcriptional factor with several of the foregoing genes (that is, the Wnt signaling pathway and ADAMTS15) supports the hypothesis that a coordinated deregulation taking place in DCs may play an important role in SpA pathogenesis.

e. deregulation of major industries.

Not the deregulation of derivatives in 2000.

Take airline deregulation in rural areas, or the partial deregulation of power in California.

A stepwise deregulation of all interregional passenger rail services in Sweden was legally completed in 2010.

He also opposed the deregulation of the power industry.