In most tumours there was a coordinated decrease in both of these clusters, but we observed that in some tumours these facets of phenotype change were uncoupled.
We showed a coordinated decrease in the expression of hKLKs 6, 7, 8 and 13 (in terms of mRNA and protein) as the metastatic signature emerges, suggesting a role of these proteases in the epithelial-mesenchymal transition of PCM cells.
A pathway approach has been able, for example, to identify a coordinated decrease in the expression of functional signals in human diabetes [ 16].
This study was the first to report a coordinated decrease in mRNA expression levels of hKLKs (KLK6, KLK7, KLK8 and KLK13) as melanoma cells emerges from primary to metastatic phenotype, suggesting a role of these proteases in the epithelial-mesenchymal transition of primary melanoma cells.
In the same cohort of samples, a coordinated decrease in the NICD protein levels was once again detected in the RND3 transfected group (Fig. 5D, the Input section).
Future studies measuring a coordinated decrease in ceramide with increased SM levels are warranted.
Turn rates vs time for Or42a > CsChrimson larvae responding to coordinated increases and decreases of red and blue light.
After cutting and then relaxing for a while, the numbers of sixfold and sevenfold coordinated atoms decrease rapidly until they settle out, and the sevenfold coordinated atoms seem to disappear.
Moreover, we observed a decrease of in the number of rehospitalisations in the first 12 months for non-ACS chest pain, and fewer visits to the cardiac emergency room in patients attending the nurse-coordinated prevention programme.
Our results show that the coordinated care decreases the number of hospital admissions and the rate of functional deterioration and appears to delay mortality.
