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Future studies measuring a coordinated decrease in ceramide with increased SM levels are warranted.
In the same cohort of samples, a coordinated decrease in the NICD protein levels was once again detected in the RND3 transfected group (Fig. 5D, the Input section).
In most tumours there was a coordinated decrease in both of these clusters, but we observed that in some tumours these facets of phenotype change were uncoupled.
A pathway approach has been able, for example, to identify a coordinated decrease in the expression of functional signals in human diabetes [ 16].
We showed a coordinated decrease in the expression of hKLKs 6, 7, 8 and 13 (in terms of mRNA and protein) as the metastatic signature emerges, suggesting a role of these proteases in the epithelial-mesenchymal transition of PCM cells.
This study was the first to report a coordinated decrease in mRNA expression levels of hKLKs (KLK6, KLK7, KLK8 and KLK13) as melanoma cells emerges from primary to metastatic phenotype, suggesting a role of these proteases in the epithelial-mesenchymal transition of primary melanoma cells.
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The coordinated decrease of genes encoding iron and heme proteins may have also influenced redox status.
In summary, we showed that a cascade of coordinated mechanisms, involving tight junction alterations, decrease in merlin levels, SC migration, increase of the chemo-responsivity, YAP downregulation and redistribution, altogether reduce Hippo pathway activation in SC.
Therefore, incubation of the Aβ42 with the Eu3+-coordinated LUVs showed a 56-fold decrease in membrane permeation relative to LUVs incubated in the absence of Eu3+ (Fig. 2).
The reason nc−1/3 trends linearly with CE is attributed to the decrease in the fraction of low-coordinated (surface) sites observed on the NCs as the cluster size increases51.
Acoustic coordinated reset neuromodulation caused a statistically and clinically significant decrease in TBF-12 scores as well as in CGI-I7 after 12 months of therapy under real life conditions.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com